Cell-penetrating peptide
نویسندگان
چکیده
منابع مشابه
Evaluation of Cell Penetrating Peptide Delivery System on HPV16E7 Expression in Three Types of Cell Line
Background: The poor permeability of the plasma and nuclear membranes to DNA plasmids are two major barriers for the development of these therapeutic molecules. Therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. Objectives: The aim of this study was to investigate the in vitro delivery of plasmid DNA encoding HPV16 E7 gene...
متن کاملCell-penetrating-peptide-mediated siRNA lung delivery.
The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human disease. However, the major obstacle to its use has been the difficulty in delivering these large anionic molecules in vivo. A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penet...
متن کاملCell-based GATA4 cardiac gene transfer using cell-penetrating peptide.
Congestive heart failure (CHF) is the only cardiovascular disease that is increasing in prevalence.1 Patients with CHF who have symptoms with mild activity or at rest (Class III and Class IV) have a poor long-term outcome, with 5-year age-adjusted mortality of 50%.2,3 Heart transplantation has an 80% 5-year survival rate, but only 3000 cardiac transplants are performed in the US each year, wher...
متن کاملevaluation of cell penetrating peptide delivery system on hpv16e7 expression in three types of cell line
background: the poor permeability of the plasma and nuclear membranes to dna plasmids are two major barriers for the development of these therapeutic molecules. therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. objectives: the aim of this study was to investigate the in vitro delivery of plasmid dna encoding hpv16 e7 gene ...
متن کاملCharacterization of a Cell‐Penetrating Peptide with Potential Anticancer Activity
Cell-penetrating peptides (CPPs) are still an interesting and viable alternative for drug delivery applications. CPPs contain considerably high amounts of positively charged amino acids, imparting them with cationic character. Tumor cells are characterized by an enhanced anionic nature of their membrane surface, a property that could be used by CPPs to target these cells. We recently identified...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2013
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.141.220